Zoltan Istvan's The Transhumanist Wager is a philosophical novel that explores the conflict between transhumanist ideals and traditional societal norms. The story follows Jethro Knights, a transhumanist advocate who is willing to risk everything to achieve his vision of immortality and human enhancement. As Knights faces opposition from religious and political forces, the novel raises thought-provoking questions about the nature of humanity and the pursuit of technological progress.